大肠杆菌丝氨酸转运RNA反密码子中的核苷酸变化导致supD琥珀抑制。
A nucleotide change in the anticodon of an Escherichia coli serine transfer RNA results in supD-amber suppression.
作者信息
Steege D A
出版信息
Nucleic Acids Res. 1983 Jun 11;11(11):3823-32. doi: 10.1093/nar/11.11.3823.
Abstract
The tRNAs specified by the wild type and amber suppressor alleles of the Escherichia coli supD gene have been identified, and their primary structures determined. The sequences differ by a single nucleotide in the middle of the anticodon. A CUA anticodon allows the suppressor tRNA to read the UAG stop codon; the CGA anticodon in the minor serine tRNA species from which the suppressor is derived is specific for the serine codon UCG.
摘要
已经鉴定出由大肠杆菌supD基因的野生型和琥珀抑制基因等位基因所指定的tRNA，并确定了它们的一级结构。这些序列在反密码子中间有一个核苷酸的差异。CUA反密码子使抑制tRNA能够读取UAG终止密码子；抑制tRNA所源自的次要丝氨酸tRNA种类中的CGA反密码子对丝氨酸密码子UCG具有特异性。
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