Greenlee J E
Prog Clin Biol Res. 1983;105:325-42.
The interaction of a murine papovavirus, K virus, with its natural host, the mouse, has been studied as a possible means of gaining insight into papovavirus infections of man. These investigations have delineated the pathogenesis of K virus infection in suckling, weanling, and adult animals, have demonstrated that the virus does not produce transplacental infection, and have shown that the virus has a strong affinity for vascular endothelium but does not appear to replicate in epithelial cells in kidneys, ureters, or bladder. Preliminary work suggests that, within brains, the virus replicates not only in capillary endothelial cells but also in astrocytes and perineuronal satellite cells. In animals surviving acute infection, K virus produces protracted infection of scattered cells within multiple organs including brains and is capable of persisting despite high titers of circulating antibody. K virus infection of mice provides a useful model of acute and persistent infection by a member of the papovavirus group.
已对一种鼠乳头瘤多瘤病毒——K病毒与其天然宿主小鼠之间的相互作用进行了研究，以此作为深入了解人类乳头瘤多瘤病毒感染的一种可能手段。这些研究已经阐明了K病毒在乳鼠、断奶小鼠和成年动物中的感染发病机制，证明该病毒不会产生经胎盘感染，还表明该病毒对血管内皮细胞有很强的亲和力，但似乎不在肾脏、输尿管或膀胱的上皮细胞中复制。初步研究表明，在脑内，该病毒不仅在毛细血管内皮细胞中复制，还在星形胶质细胞和神经元周围卫星细胞中复制。在急性感染后存活的动物中，K病毒会在包括脑在内的多个器官内的散在细胞中产生持续性感染，并且尽管循环抗体滴度很高，仍能够持续存在。小鼠的K病毒感染为乳头瘤多瘤病毒组中的一种病毒引发的急性和持续性感染提供了一个有用的模型。
