Neistadt E L, Gershanovich M L, Kolygin B A, Ogorodnikova B N, Fedoreev G A, Chekharina E A, Filov V A
Neoplasma. 1978;25(1):91-4.
Chromosomal aberrations in bone marrow and lymph node cells have been investigated in 47 patients with lymphogranulomatosis 24--72 hr after administration of a single therapeutic dose of cyclophosphan and natulan. It is shown that the injurious action of cyclophosphan and natulan lasts more than 72 hr. An analysis of the dynamics of various types of chromosomal aberrations testifies that cyclophosphan and natulan affect cellular constituents found in the synthetic or post-synthetic phases of the cell cycle.
对47例淋巴肉芽肿患者在单次治疗剂量的环磷酰胺和甲基苄肼给药后24至72小时，对其骨髓和淋巴结细胞中的染色体畸变进行了研究。结果表明，环磷酰胺和甲基苄肼的损伤作用持续超过72小时。对各种类型染色体畸变动态的分析表明，环磷酰胺和甲基苄肼会影响细胞周期合成期或合成后期的细胞成分。
