拉希德大鼠肉瘤病毒癌基因的核苷酸序列：新突变
Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations.
作者信息
Rasheed S, Norman G L, Heidecker G
出版信息
Science. 1983 Jul 8;221(4606):155-7. doi: 10.1126/science.6344220.
PMID:6344220
Abstract
The nucleotide sequence of the oncogene of the Rasheed strain of rat sarcoma virus was determined. The oncogene (Ra-v-ras) encodes a 29,000-dalton (p29) transforming protein. This protein is distinct from the immunologically related 21,000-dalton protein (p21) of the Harvey murine sarcoma virus in its amino terminus and in having additional mutations in its carboxyl terminus. Although the functional significance of these changes is unknown, they appear to occur only in rat sarcoma virus.
摘要
已确定大鼠肉瘤病毒拉希德株癌基因的核苷酸序列。该癌基因（Ra-v-ras）编码一种29000道尔顿（p29）的转化蛋白。这种蛋白质在氨基末端以及羧基末端存在额外突变，这使其与哈维鼠肉瘤病毒免疫相关的21000道尔顿蛋白质（p21）不同。尽管这些变化的功能意义尚不清楚，但它们似乎仅在大鼠肉瘤病毒中出现。
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