McIrvine A J, Mannick J A
Surg Clin North Am. 1983 Apr;63(2):245-61. doi: 10.1016/s0039-6109(16)42980-4.
Lymphocyte function is commonly altered in critical ill surgical patients. There is controversy whether or not formation of antibodies is impaired; however, cellular immune responses are routinely depressed. Patients who have suffered major surgical or accidental trauma or burns frequently become anergic. Their lymphocytes respond poorly to mitogenic or antigenic stimulation, and serum factors suppressive of lymphocyte activation appear. Mechanisms underlying these abnormalities remain to be defined.
重症外科患者的淋巴细胞功能通常会发生改变。抗体形成是否受损存在争议；然而，细胞免疫反应通常会受到抑制。经历重大手术、意外创伤或烧伤的患者常常会出现无反应性。他们的淋巴细胞对有丝分裂原或抗原刺激反应不佳，并且会出现抑制淋巴细胞活化的血清因子。这些异常背后的机制仍有待确定。
