Di Padova F, Di Padova C, Rovagnati P, Tritapepe R
Clin Exp Immunol. 1986 Sep;65(3):582-8.
Lymphoblastoid B cells, spontaneously secreting specific antibodies of IgG and IgA classes, are constantly detected after in-vivo immunization and represent a sensitive marker of a recent antigenic exposure. In this study we demonstrate that surgical trauma is followed, at a well-defined time after surgery, by the appearance of circulating lymphoblastoid B cells spontaneously secreting IgG and IgA. The kinetics and the functional behaviour of this B cell subset are identical to those of lymphoblastoid B cells observed after in-vivo immunization. Our data indicate that surgical trauma activates a humoral immune response. Antigens released by traumatized tissues or encountered through breaches in skin or mucous membranes might initiate the reaction.
在体内免疫后，可不断检测到自发分泌IgG和IgA类特异性抗体的淋巴母细胞样B细胞，它们是近期抗原暴露的敏感标志物。在本研究中，我们证明，手术创伤后在手术的特定时间会出现自发分泌IgG和IgA的循环淋巴母细胞样B细胞。该B细胞亚群的动力学和功能行为与体内免疫后观察到的淋巴母细胞样B细胞相同。我们的数据表明，手术创伤激活了体液免疫反应。创伤组织释放的或通过皮肤或粘膜破损接触到的抗原可能引发该反应。
