Williams J W, Peters T G, Haggitt R, Van Voorst S
Surg Gynecol Obstet. 1983 Jun;156(6):767-73.
Orthotopic hepatic transplantation was performed upon 29 dogs. Four dogs received no immunosuppressant, 12 received cyclosporine and 13 received azathioprine. Dogs treated with cyclosporine at a dose of 20 milligrams per kilogram yielded histologic and functional data indistinguishable from those of the dogs in the sham transplant group. Histologic evidence of rejection consistently appeared when the dose was decreased to 10 milligrams per kilogram but was reversed upon resuming the administration of the higher dosage. Serum levels of bilirubin and hepatic enzymes, serum glutamic-oxalacetic transaminase, serum glutamic-pyruvic transaminase and alkaline phosphatase did not correlate with the development or resolution of histologic evidence of rejection in dogs receiving cyclosporine. Dogs receiving cyclosporine for 60 days had a prolonged survival when the drug was stopped, whereas the dogs receiving such therapy for less than 60 days did not have a prolonged survival period.
对29只狗进行了原位肝移植。4只狗未接受免疫抑制剂，12只接受环孢素，13只接受硫唑嘌呤。以每千克20毫克的剂量用环孢素治疗的狗产生的组织学和功能数据与假移植组的狗无法区分。当剂量降至每千克10毫克时，排斥反应的组织学证据持续出现，但在恢复较高剂量给药后逆转。接受环孢素的狗的血清胆红素和肝酶水平、血清谷草转氨酶、血清谷丙转氨酶和碱性磷酸酶与排斥反应组织学证据的出现或消退无关。接受环孢素治疗60天的狗在停药后存活期延长，而接受该治疗少于60天的狗没有延长的存活期。
