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[与传统左旋多巴制剂相比,长效左旋多巴(美多巴缓释片)有效性的初步评估]

[Preliminary assessment of the effectiveness of L-dopa with prolonged action (Medidopa retard) as compared to conventional L-dopa preparation].

作者信息

Friedman A

出版信息

Neurol Neurochir Pol. 1978 Jan-Feb;12(1):39-43.

PMID:634431
Abstract

The therapeutic effectiveness of a L-DOPA preparation of sustained action was established in 9 patients with parkinsonism on the basis of a neurological parkinsonism scale and Northwestern University Disability Scale. The investigations were carried out by the method of cross test with conventional L-DOPA preparation (Larodopa). In these investigations no higher effectiveness of the retard form was shown. Side effects during administration of the retard form were more frequent and more intense than during administration of the conventional drug.

摘要

基于帕金森病神经量表和西北大学残疾量表,对9例帕金森病患者确定了一种长效左旋多巴制剂的治疗效果。采用与传统左旋多巴制剂(美多巴)交叉试验的方法进行研究。在这些研究中,未显示缓释剂型有更高的疗效。与使用传统药物相比,使用缓释剂型时副作用更频繁、更严重。

相似文献

1
[Preliminary assessment of the effectiveness of L-dopa with prolonged action (Medidopa retard) as compared to conventional L-dopa preparation].[与传统左旋多巴制剂相比,长效左旋多巴(美多巴缓释片)有效性的初步评估]
Neurol Neurochir Pol. 1978 Jan-Feb;12(1):39-43.
2
[Experience with a l-dopa retard preparation in the peroral long-term therapy of the Parkinsonian syndrome].[左旋多巴缓释制剂在帕金森综合征口服长期治疗中的经验]
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[Slow-release L-dopa vs. standard L-dopa in Parkinson patients in various stages of the disease. Studies of pharmacokinetics and motor effectiveness].[缓释左旋多巴与标准左旋多巴治疗帕金森病各阶段患者的疗效比较。药代动力学及运动效能研究]
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5
[Comparison between results achieved by administering L-dopa and Sinemet in parkinsonism in the light of our records].
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[Long-term l-DOPA therapy for parkinsonism and its pathochemical aspect].
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(12):1810-3.
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8
[Results of L-dopa treatment of parkinsonism].
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[Effectiveness of slow release L-DOPA/benserazide in treatment of end-of-dose akinesia in Parkinson disease].[缓释左旋多巴/苄丝肼治疗帕金森病剂末运动不能的疗效]
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[Use of the preparation L-dopa in parkinsonism].
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