Romero S, Chouza C, Gomensoro J B
Neurol Neurocir Psiquiatr. 1976;17(4):239-54.
Eighty-one Parkinsonic patients were treated with L-dopa alone and/or combined with Ro4-4602, during 27 to 60 months. The results are reported. 7.2% of the patients, who are still being treated, showed good, very good or excellent results. There was a relation between the duration of the illness and the degree of improvement, the most prolonged Parkinsonisms showed the least improvement. The 4:1 proportion of L-dopa and Ro4-4602 was more effective than the 3:2. Adding small amounts of L-dopa to the combinations improvement and secondary effects increased. No advantages were found using high combined dosages. The main secondary effects at the end of treatment were abnormal movements (45% of cases) and distonic attitudes (53%). Patients who stoped the medication showed less sustained improvement and a high degree of Parkinsonism. This reveals that Parkinson's disease continues to envolve in spite of the medication. The "long-term syndrome" includes the late decrease of effectiveness of the drugs and/or the increase of secondary effects.
81名帕金森病患者单独使用左旋多巴和/或联合使用Ro4-4602进行治疗，疗程为27至60个月。现将结果报告如下。仍在接受治疗的患者中有7.2%显示出良好、非常好或极好的效果。疾病持续时间与改善程度之间存在关联，病程最长的帕金森病患者改善最少。左旋多巴与Ro4-4602按4:1比例联合使用比按3:2比例更有效。在联合用药中添加少量左旋多巴，改善效果和副作用都会增加。高剂量联合用药未发现优势。治疗结束时的主要副作用是异常运动（45%的病例）和张力障碍姿势（53%）。停药的患者改善效果维持时间较短，帕金森症状严重。这表明尽管使用了药物，帕金森病仍在继续发展。“长期综合征”包括药物疗效后期下降和/或副作用增加。
