奎宁在低于哺乳动物和哺乳动物系统中的致突变性测试。

Mutagenicity testing of quinine with submammalian and mammalian systems.

作者信息

Münzner R, Renner H W

出版信息

Toxicology. 1983 Feb;26(2):173-8. doi: 10.1016/0300-483x(83)90068-9.

Abstract

Quinine hydrochloride was assayed for genotoxic activity by using 4 different test systems with distinct genetic endpoints. No indications for point mutations were observed in the Ames system. In 3 cytogenetic tests performed on small rodents, Chinese hamsters showed no genotoxic activity, while inbred strains of mice revealed a dose dependent increase of SCEs, enhanced incidence of micronuclei and elevated chromatid breaks.

摘要

采用4种具有不同遗传终点的不同测试系统对盐酸奎宁的遗传毒性活性进行了测定。在艾姆斯试验系统中未观察到点突变的迹象。在对小型啮齿动物进行的3项细胞遗传学试验中，中国仓鼠未显示出遗传毒性活性，而近交系小鼠则显示出姐妹染色单体交换呈剂量依赖性增加、微核发生率增加以及染色单体断裂增加。