Shimizu T, Kubota S, Kito K, Kitamura K
No Shinkei Geka. 1978 Feb;6(2):153-9.
Incidence of postoperative meningitis by gram-negative bacilli infection, so called "opportunistic infections", has recently increased in the neurosurgical field. The opportunistic infection is caused by suppression of the host's immunity and consequently limitation of the host defense mechanisms. Based on the results obtained from 4 cases of postoperative severe meningitis presented here, the authors concluded as follows: 1) Special care must be taken for intrathecal injection of antibiotics because of causing paralytic ileus, convulsion and paraparesis of the lower limbs. 2) The combined use of intravenous immunoglobulin (Gamma-Venin) and antibiotics produced potentiated effects. Accordingly, the amplification of the host's immunity is of major importance for the treatment of severe meningitis. 3) Using immunoadherence hemagglutination test of patient's CSF and the serum, it is considerably easier to determine whether or not to withdraw antibiotics.
在神经外科领域，由革兰氏阴性杆菌感染引起的术后脑膜炎（即所谓的“机会性感染”）的发生率近来有所上升。机会性感染是由宿主免疫力受到抑制以及随之而来的宿主防御机制受限所导致的。基于本文所呈现的4例术后严重脑膜炎病例的结果，作者得出如下结论：1）由于鞘内注射抗生素会引发麻痹性肠梗阻、惊厥以及下肢轻瘫，因此必须特别小心。2）静脉注射免疫球蛋白（伽马静脉宁）与抗生素联合使用产生了增效作用。因此，增强宿主免疫力对于治疗严重脑膜炎至关重要。3）通过对患者脑脊液和血清进行免疫黏附血凝试验，能更轻松地确定是否停用抗生素。
