可乐定对生长激素缺乏症的检测比胰岛素低血糖试验更好。
Clonidine is a better test for growth hormone deficiency than insulin hypoglycaemia.
作者信息
Fraser N C, Seth J, Brown N S
出版信息
Arch Dis Child. 1983 May;58(5):355-8. doi: 10.1136/adc.58.5.355.
Abstract
The oral clonidine test was compared with the standard intravenous insulin hypoglycaemia test in 41 children and adolescents with short stature. In those without growth hormone deficiency clonidine provoked a significantly higher mean plasma growth hormone response and gave fewer false subnormal responses (apparent growth hormone deficiency) than insulin. Children with psychosocial deprivation had poorer responses to both tests. In view of these findings and the absence of unacceptable side effects with clonidine it is concluded that the oral administration of this alpha-adrenergic stimulant is a safe and reliable alternative test of growth hormone release.
摘要
对41名身材矮小的儿童和青少年进行了口服可乐定试验，并与标准静脉注射胰岛素低血糖试验进行了比较。在那些没有生长激素缺乏的患者中，可乐定引起的平均血浆生长激素反应明显更高，且与胰岛素相比，假低于正常反应（明显的生长激素缺乏）更少。患有心理社会剥夺的儿童对这两种试验的反应都较差。鉴于这些发现以及可乐定没有不可接受的副作用，得出结论：口服这种α-肾上腺素能兴奋剂是一种安全可靠的生长激素释放替代试验。
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