静脉注射胰岛素和口服可乐定生长激素分泌耐量试验的比较。卫生服务人类生长激素委员会。
Comparison of the intravenous insulin and oral clonidine tolerance tests for growth hormone secretion. The Health Services Human Growth Hormone Committee.
出版信息
Arch Dis Child. 1981 Nov;56(11):852-4. doi: 10.1136/adc.56.11.852.
The plasma growth hormone response to intravenous insulin was compared with that of oral clonidine in a multicentre trial in 64 patients being investigated for short stature. Either test was judged to give a positive result if the maximum plasma growth hormone concentration was at least 20 mU/1. In 42 pairs of tests concordant results were obtained, 19 being positive and 23 negative. In 12 tests only the response to insulin was positive and 10 tests were positive only for clonidine. Clonidine caused symptoms due to hypotension in some patients but the incidence and severity of side effects varied greatly between centres. It is concluded that clonidine and insulin have similar reliability as test of growth hormone secretion, but that clonidine may be the safer.
在一项针对64名身材矮小患者的多中心试验中，比较了静脉注射胰岛素和口服可乐定后血浆生长激素的反应。如果最大血浆生长激素浓度至少为20 mU/1，则两种测试中的任何一种都被判定为阳性结果。在42对测试中获得了一致的结果，19例为阳性，23例为阴性。在12次测试中，仅胰岛素反应为阳性，10次测试仅可乐定反应为阳性。可乐定在一些患者中引起了由于低血压导致的症状，但各中心之间副作用的发生率和严重程度差异很大。结论是，可乐定和胰岛素作为生长激素分泌测试具有相似的可靠性，但可乐定可能更安全。
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