Kernell A, Arnqvist H
Arch Ophthalmol. 1983 Jun;101(6):968-70. doi: 10.1001/archopht.1983.01040010968025.
Eighteen rats were made diabetic with a single intravenous dose of streptozocin; 16 rats served as nondiabetic controls. Fluorescein sodium was injected into the tail vein for fluorophotometry. After insulin therapy, metabolic control was improved in the diabetic animals, but normoglycemia was not achieved. The vitreous fluorescein level in diabetic animals was significantly higher than in controls before insulin treatment, but it decreased after six to seven days of insulin therapy. There was no significant alteration of the fluorescein concentration in the vitreous body of the controls when vitreous fluorophotometry was repeated after six to seven days. The plasma fluorescein concentration was lower in the diabetic than in the nondiabetic animals and unaltered after insulin treatment. The results imply that the dysfunction of the blood-retinal barrier in the diabetic rats is reversible by insulin therapy. It is probably related to the diabetic state and not to a toxic effect of streptozocin.
18只大鼠通过单次静脉注射链脲佐菌素制成糖尿病模型；16只大鼠作为非糖尿病对照。将荧光素钠注入尾静脉进行荧光光度测定。胰岛素治疗后，糖尿病动物的代谢控制得到改善，但未实现血糖正常。糖尿病动物的玻璃体荧光素水平在胰岛素治疗前显著高于对照组，但在胰岛素治疗六至七天后降低。六至七天后重复玻璃体荧光光度测定时，对照组玻璃体中的荧光素浓度无显著变化。糖尿病动物的血浆荧光素浓度低于非糖尿病动物，且胰岛素治疗后无变化。结果表明，胰岛素治疗可使糖尿病大鼠的血视网膜屏障功能障碍逆转。这可能与糖尿病状态有关，而与链脲佐菌素的毒性作用无关。
