Volden G, Thorud E, Iversen O H
Br J Dermatol. 1983 Jul;109 Suppl 25:133-6. doi: 10.1111/j.1365-2133.1983.tb06825.x.
The effects of dimethyl sulphoxide (DMSO) are in some respects similar to those of retinoids. DMSO has the ability to penetrate cellular membranes and to enhance the penetration of other molecules. It may be reasonable to assume that DMSO treatment results in differentiation of cells, possibly through membrane-mediated events. This may be of importance for the study of the carcinogenic process. The release of a certain amount of lysosomal enzymes to the extracellular space is a normal function of the cell (Hickman & Neufeld, 1972), and a certain release of the cytoplasmic and lysosomal enzymes to the extracellular space is not necessarily deleterious for the cells (Volden, Haugen & Skrede, 1980). The purpose of the present investigation was to study the possible effects of DMSO on methylcholanthrene-induced skin carcinogenesis. Since the uptake of lysosomal enzymes by cultured cells appears to involve a membrane receptor process, the effects of the carcinogen and the solvents on the rate of secretion of lysosomal enzymes and lactate dehydrogenase from HeLa cells were investigated.
二甲基亚砜（DMSO）的作用在某些方面与类视黄醇相似。DMSO能够穿透细胞膜并增强其他分子的穿透能力。可以合理推测，DMSO处理可能通过膜介导的事件导致细胞分化。这对于致癌过程的研究可能具有重要意义。一定量的溶酶体酶释放到细胞外空间是细胞的正常功能（希克曼和诺伊费尔德，1972年），细胞质和溶酶体酶向细胞外空间的一定程度释放不一定对细胞有害（沃尔登、豪根和斯克雷德，1980年）。本研究的目的是探讨DMSO对甲基胆蒽诱导的皮肤致癌作用的可能影响。由于培养细胞对溶酶体酶的摄取似乎涉及膜受体过程，因此研究了致癌物和溶剂对HeLa细胞溶酶体酶和乳酸脱氢酶分泌速率的影响。
