胸腺素（一种胸腺激素）孵育后骨髓玫瑰花结形成细胞中T细胞标志物的出现情况。
Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone.
作者信息
Bach J F, Dardenne M, Goldstein A L, Guha A, White A
出版信息
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2734-8. doi: 10.1073/pnas.68.11.2734.
Abstract
After incubation with thymosin, a thymic hormone, normal bone marrow rosette-forming cells acquire T-cell characteristics, including increased sensitivity to azathioprine, anti-lymphocyte serum, and anti-theta serum. This activity of thymosin provides a new sensitive and reproducible bioassay for thymosin, and is well correlated with an in vivo graft-versus-host assay. In addition, incubation of spleen cells from adult thymectomized mice with thymosin in vitro restores to normal their diminished sensitivity to azathioprine and anti-lymphocte serum.
摘要
在用胸腺素（一种胸腺激素）孵育后，正常骨髓玫瑰花结形成细胞获得T细胞特性，包括对硫唑嘌呤、抗淋巴细胞血清和抗θ血清的敏感性增加。胸腺素的这种活性为胸腺素提供了一种新的灵敏且可重复的生物测定方法，并且与体内移植物抗宿主测定法密切相关。此外，将成年去胸腺小鼠的脾细胞在体外用胸腺素孵育，可使其对硫唑嘌呤和抗淋巴细胞血清降低的敏感性恢复正常。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
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J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
3
Graft versus host reactions. Their natural history, and applicability as tools of research.移植物抗宿主反应。其自然史及其作为研究工具的适用性。
Prog Allergy. 1962;6:349-467.
4
In vitro evaluation of immunosuppressive drugs.免疫抑制药物的体外评估。
Nature. 1969 Jun 7;222(5197):998-9. doi: 10.1038/222998a0.
5
Influence of thymosin on immunological competence of lymphoid cells from thymectomized mice.胸腺素对去胸腺小鼠淋巴细胞免疫活性的影响。
Nature. 1968 Sep 28;219(5161):1391-2. doi: 10.1038/2191391a0.
6
In vivo specific antigen recognition by rosette forming cells.体内玫瑰花结形成细胞对特异性抗原的识别。
Nature. 1970 Sep 19;227(5264):1251-2. doi: 10.1038/2271251a0.
7
Acceleration of lymphoid tissue regeneration in x-irradiated CBA-W mice by injection of thymosin.注射胸腺素对受X射线照射的CBA-W小鼠淋巴组织再生的促进作用
Radiat Res. 1970 Mar;41(3):579-93.
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