催化由醇类生物合成离子型烷氧基脂质的酶的底物特异性。

Substrate specificity of enzymes catalyzing the biosynthesis of ionic alkoxylipids from alcohols.

作者信息

Bandi Z L, Mangold H K

出版信息

Nutr Metab. 1978;22(3):190-9. doi: 10.1159/000176215.

DOI:10.1159/000176215

Abstract

An equimolar mixture of homologous saturated alcohols (13:0, 15:0, 17:0, 19:0) and an equimolar mixture of vinylogous alcohols (19:0, 19:1, 19:2) were fed to two groups of rats. All of the odd-numbered alcohols were incorporated into the ionic alkoxylipids of the rats' small intestine. Pronounced quantitative differences in the distribution of the various odd-numbered alkyl and alk-1-enyl moieties of choline phosphoglycerides and ethanolamine phosphoglycerides gave evidence to differences in the specificity of the enzyme system catalyzing the biosynthesis of alkoxylipids from long-chain alcohols.

摘要

将等摩尔的同系饱和醇混合物（13:0、15:0、17:0、19:0）和等摩尔的乙烯醇混合物（19:0、19:1、19:2）喂给两组大鼠。所有奇数碳醇都被整合到大鼠小肠的离子型烷氧基脂质中。胆碱磷酸甘油酯和乙醇胺磷酸甘油酯的各种奇数碳烷基和alk-1-烯基部分在分布上存在明显的定量差异，这证明了催化由长链醇生物合成烷氧基脂质的酶系统在特异性上存在差异。

相似文献

1

Substrate specificity of enzymes catalyzing the biosynthesis of ionic alkoxylipids from alcohols.催化由醇类生物合成离子型烷氧基脂质的酶的底物特异性。

Nutr Metab. 1978;22(3):190-9. doi: 10.1159/000176215.

2

Chain length specificity in the utilization of long chain alcohols for ether lipid biosynthesis in rat brain.大鼠脑中利用长链醇进行醚脂生物合成的链长特异性

Lipids. 1977 Oct;12(10):872-5. doi: 10.1007/BF02533279.

3

Formation of ether lipids and wax esters in mammalian cells. Specificity of enzymes with regard to carbon chains of substrates.哺乳动物细胞中醚脂和蜡酯的形成。酶对底物碳链的特异性。

Biochim Biophys Acta. 1982 May 13;711(2):197-207. doi: 10.1016/0005-2760(82)90027-3.

4

Competing pathways in the formation of alkyl, alk-1-enyl and acyl moieties in the lipids of mammalian tissues.哺乳动物组织脂质中烷基、烯丙基和酰基部分形成过程中的竞争途径。

Eur J Biochem. 1980;107(1):289-94. doi: 10.1111/j.1432-1033.1980.tb04649.x.

5

The alkyl and alk-1-enyl glycerols in the liver of rats fed long-chain alcohols or alkyl glycerols.喂食长链醇或烷基甘油的大鼠肝脏中的烷基和链-1-烯基甘油。

FEBS Lett. 1971 Jan 25;12(4):217-220. doi: 10.1016/0014-5793(71)80024-8.

6

Metabolism of unusual lipids in the rat. I. Formation of unsaturated alkyl and alk-I-enyl chains from orally administered alcohols.大鼠体内特殊脂质的代谢。I. 口服醇类形成不饱和烷基链和烯基链。

Biochim Biophys Acta. 1971 Sep 1;239(3):357-67. doi: 10.1016/0005-2760(71)90027-0.

7

Biosynthesis of alkyl glycerol lipids in the intestinal mucosa in vivo and in a cell-free system.

Biochim Biophys Acta. 1972 Mar 23;260(3):345-51. doi: 10.1016/0005-2760(72)90048-3.

8

Metabolism of drugs. LXXX. The metabolic fate of nitrofuran derivatives. 3. Studies on enzymes in small intestinal mucosa of rat catalyzing degradation of nitrofuran derivatives.药物代谢。八十。硝基呋喃衍生物的代谢命运。3. 大鼠小肠黏膜中催化硝基呋喃衍生物降解的酶的研究。

Chem Pharm Bull (Tokyo). 1973 Mar;21(3):622-8. doi: 10.1248/cpb.21.622.

9

Composition of O-alkyl and O-alk-1-enyl moieties in the glycerolipids of the human adrenal.人肾上腺甘油脂质中O-烷基和O-链-1-烯基部分的组成

Lipids. 1977 Jul;12(7):620-5. doi: 10.1007/BF02533392.

10

Metabolism of the enantiomeric I-O-alkyl glycerol ethers in the rat intestinal mucosa in vivo; incorporation into I-O-alkyl and I-O-alk-I'-enyl glycerol lipids.

Biochim Biophys Acta. 1971 Jun 8;239(1):38-46. doi: 10.1016/0005-2760(71)90190-1.

引用本文的文献

1

Metabolism of long-chain fatty acids, alcohols and alkylglycerols in the fish parasite Paratenuisentis ambiguus (Acanthocephala).鱼类寄生虫模糊副新棘虫（棘头虫纲）中长链脂肪酸、醇类和烷基甘油的代谢

Lipids. 1994 Aug;29(8):583-9. doi: 10.1007/BF02536631.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验