Natarajan V, Schmid H H
Lipids. 1977 Oct;12(10):872-5. doi: 10.1007/BF02533279.
A mixture of cis-9[1(-14)C] octadecenol and [1(-14)C] docosanol was injected into the brains of 19-day-old rats, and incorporation of radioactivity into brain lipids was determined after 3, 12, and 24 hr. Both alcohols were metabolized by the brain but at different rates; each was oxidized to the corresponding fatty acid, but oleic acid was more readily incorporated into polar lipids. Substantial amounts of radioactivity were incorporated into 18:1 alkyl and alk-1-enyl moieties of the ethanolamine phosphoglycerides and into 18:1 alkyl moieties of the choline phosphoglycerides. Even after the disappearance of the 18:1 alcohol from the substrate mixture (12 hr), the 22:0 alcohol was not used to any measurable extent for alkyl and alk-1-enylglycerol formation.
将顺式-9[1(-14)C]十八碳烯醇和[1(-14)C]二十二醇的混合物注入19日龄大鼠的脑内，并在3小时、12小时和24小时后测定放射性掺入脑脂质的情况。两种醇均被脑代谢，但速率不同；每种醇都被氧化成相应的脂肪酸，但油酸更易掺入极性脂质中。大量放射性掺入乙醇胺磷酸甘油酯的18:1烷基和alk-1-烯基部分以及胆碱磷酸甘油酯的18:1烷基部分。即使底物混合物中的18:1醇消失后（12小时），22:0醇也未被用于任何可测量程度的烷基和alk-1-烯基甘油的形成。
