Argilés J, Herrera E
Diabetologia. 1983 Apr;24(4):300-3. doi: 10.1007/BF00282718.
In sham-operated rats, intravenous administration of 14C-very low density lipoprotein triglycerides (with labelled esterified fatty acids) caused an initial decrease and subsequent increase in plasma 14C-lipids of both very low density lipoproteins (VLDL) (density less than 1.006) and lipoproteins of density greater than 1.019. There was a similar change in 14C-lipids in adipose tissue and heart whereas in kidney, spleen and liver, 14C-lipids increased initially and then decreased. Insulin treatment in sham-operated animals decreased circulating 14C-lipids in VLDL and in lipoproteins of density greater than 1.019, while intermediate density (1.006-1.019) lipoproteins increased. Insulin also enhanced the radioactivity retained in spleen. In functionally hepatectomized rats, 14C-lipids progressively increased in heart. Insulin treatment in these rats enhanced the disappearance from circulation of 14C-VLDL and of lipoproteins of density greater than 1.019, as well as the appearance of 14C-intermediate density lipoproteins. The appearance of 14C-lipids in white adipose tissue also was augmented, while it decreased in heart and lung. Thus, in sham-operated animals, insulin apparently stimulates the uptake of products of VLDL metabolism by cells in the reticuloendothelial system, while in functionally hepatectomized rats there is increased heart utilization of VLDL triglycerides, and insulin enhances the net extrahepatic catabolism of these lipoproteins.
在假手术大鼠中，静脉注射14C-极低密度脂蛋白甘油三酯（带有标记的酯化脂肪酸）导致血浆中极低密度脂蛋白（VLDL）（密度小于1.006）和密度大于1.019的脂蛋白的14C-脂质先减少后增加。脂肪组织和心脏中的14C-脂质有类似变化，而在肾脏、脾脏和肝脏中，14C-脂质先增加后减少。假手术动物接受胰岛素治疗后，VLDL和密度大于1.019的脂蛋白中的循环14C-脂质减少，而中密度（1.006 - 1.019）脂蛋白增加。胰岛素还增强了脾脏中保留的放射性。在功能性肝切除的大鼠中，心脏中的14C-脂质逐渐增加。这些大鼠接受胰岛素治疗后，14C-VLDL和密度大于1.019的脂蛋白从循环中的清除加快，同时14C-中密度脂蛋白出现。白色脂肪组织中14C-脂质的出现也增加，而在心脏和肺中则减少。因此，在假手术动物中，胰岛素显然刺激网状内皮系统细胞摄取VLDL代谢产物，而在功能性肝切除的大鼠中，心脏对VLDL甘油三酯的利用增加，胰岛素增强了这些脂蛋白的肝外净分解代谢。
