Steiner G
Diabetes. 1981;30(Suppl 2):1-7. doi: 10.2337/diab.30.2.s1.
Atherosclerosis is the most common complication of diabetes. Epidemiologic and pathophysiologic evidence suggest a number of possible reasons for this. They include alterations in lipoproteins, platelets, soluble clotting factors, the balance of prostacyclin-thromboxane, blood pressure regulation, and arterial smooth muscle cell metabolism and proliferation. Many of these alterations may accompany hyperinsulinemia and may account for the recent evidence that hyperinsulinemia is a risk factor for atherosclerosis. Advances in this area will require the recognition that neither diabetes nor atherosclerosis are single disorders. Furthermore, new approaches are needed to study these disorders in which there may be many years of very subtle changes before any end point is apparent.
动脉粥样硬化是糖尿病最常见的并发症。流行病学和病理生理学证据表明了一些可能的原因。它们包括脂蛋白、血小板、可溶性凝血因子、前列环素 - 血栓素平衡、血压调节以及动脉平滑肌细胞代谢和增殖的改变。其中许多改变可能伴随高胰岛素血症，并且可能解释了最近关于高胰岛素血症是动脉粥样硬化危险因素的证据。该领域的进展将需要认识到糖尿病和动脉粥样硬化都不是单一的疾病。此外，需要新的方法来研究这些疾病，因为在任何终点出现之前可能有多年非常细微的变化。
