Kubo K, Shiraishi K, Muto H, Suzuki T, Sugino N
Hypertension. 1983 Jul-Aug;5(4 Pt 2):II109-12. doi: 10.1161/01.hyp.5.4_pt_2.ii109.
The hemodynamic effects of nifedipine were studied in nine patients with acute or chronic renal failure undergoing hemodialysis. Arterial blood pressure was lowered within 15 minutes of oral administration of nifedipine 10 mg. Mean arterial pressure and total systemic peripheral resistance were significantly decreased, whereas cardiac index and heart rate revealed slight but statistically insignificant changes. Changes in pulmonary artery diastolic pressure and mean right atrial pressure which were closely related to cardiac preload were not significant. However, the antihypertensive effect was enhanced in patients with lower pretreatment preload. Results show that oral nifedipine is effective in rapidly reducing blood pressure during or following hemodialysis.
对9例接受血液透析的急慢性肾衰竭患者研究了硝苯地平的血流动力学效应。口服10mg硝苯地平后15分钟内动脉血压下降。平均动脉压和全身总外周阻力显著降低，而心脏指数和心率虽有轻微变化但无统计学意义。与心脏前负荷密切相关的肺动脉舒张压和平均右心房压变化不显著。然而，预处理前负荷较低的患者降压效果增强。结果表明，口服硝苯地平对血液透析期间或之后快速降低血压有效。
