Eliahou H E, Iaina A, Schneider R, Cohen D, Goldfarb D, Gross M
Clin Exp Dial Apheresis. 1982;6(4):229-36. doi: 10.3109/08860228209049856.
The immediate antihypertensive effect of 10 mg nifedipine sublingually (nifedipine test), was measured in 19 chronic renal failure hypertensive patients on dialysis and 34 essential hypertensive patients with normal kidney function. The blood pressure decreased significantly in both groups. The minimal values were observed between 30 and 60 minutes after the sublingual administration of nifedipine. The blood pressure decreased from 178 +/- 3.3/104.0 +/- 3.9 to 136.0 +/- 4.7/87.5 +/- 5.1 mm Hg (p less than 0.001) in dialysis patients and from 176.8 +/- 4.5/107.1 +/- 2.4 to 133.0 +/- 3.0/81.7 +/- 2.2 mm Hg in essential hypertension patients (p less than 0.001). The decrease in blood pressure during the test had a significant positive correlation with the pre-test values. Thirteen hypertensive patients on dialysis and 20 essential hypertensive patients completed 2 weeks of daily oral nifedipine therapy, with a dose of 30 to 40 mg per day. The mean blood pressure at the end of the 2 weeks of treatment decreased from 179.5 +/- 4.5/108.5 +/- 5.3 mm Hg to 154.4 +/- 6.3/82.3 +/- 2.6 mm Hg (p less than 0.001) in dialysis patients, and from 176.8 +/- 5.8/110.3 +/- 2.9 to 151.3 +/- 5.3/93.5 +/- 2.6 mm Hg (p less than 0.001) in essential hypertension patients. The present results reveal that nifedipine has a powerful immediate as well as a long-term antihypertensive action in dialysis patients with high blood pressure. This effect is similar to that obtained in essential hypertensive patients.
对19名接受透析的慢性肾衰竭高血压患者和34名肾功能正常的原发性高血压患者，测量了舌下含服10毫克硝苯地平后的即时降压效果（硝苯地平试验）。两组患者的血压均显著下降。舌下含服硝苯地平后30至60分钟观察到最低值。透析患者的血压从178±3.3/104.0±3.9毫米汞柱降至136.0±4.7/87.5±5.1毫米汞柱（p<0.001），原发性高血压患者的血压从176.8±4.5/107.1±2.4毫米汞柱降至133.0±3.0/81.7±2.2毫米汞柱（p<0.001）。试验期间血压下降与试验前值呈显著正相关。13名接受透析的高血压患者和20名原发性高血压患者完成了为期2周的每日口服硝苯地平治疗，剂量为每天30至40毫克。透析患者治疗2周结束时的平均血压从179.5±4.5/108.5±5.3毫米汞柱降至154.4±6.3/82.3±2.6毫米汞柱（p<0.001），原发性高血压患者的平均血压从176.8±5.8/110.3±2.9毫米汞柱降至151.3±5.3/93.5±2.6毫米汞柱（p<0.001）。目前的结果表明，硝苯地平对高血压透析患者有强大的即时和长期降压作用。这种作用与原发性高血压患者相似。
