Cogen R B, Garrison D C, Weatherford T W
J Periodontol. 1983 May;54(5):277-82. doi: 10.1902/jop.1983.54.5.277.
Periodontally involved extracted human teeth were either untreated or were treated with root planing, citric acid, or root planing followed by citric acid. Following incubation of the roots, in the presence of normal human gingival fibroblasts for varying periods of time, cells were assayed for viability by radioactive label (51Cr). In addition, the ability to promote attachment and growth of gingival fibroblasts, by root treatment as above, was observed. The results of multiple experiments in each category indicated strongly that none of the roots, regardless of treatment or nontreatment, had any significant adverse affect on the viability of the cells. However, only root-planed roots, whether or not citric acid was used, promoted cell attachment and growth.
牙周受累的拔除人类牙齿要么未经处理，要么接受了根面平整、柠檬酸处理，或者先进行根面平整再用柠檬酸处理。将牙根在正常人牙龈成纤维细胞存在的情况下孵育不同时间后，通过放射性标记（51Cr）检测细胞活力。此外，观察了上述牙根处理促进牙龈成纤维细胞附着和生长的能力。每类中的多次实验结果有力地表明，无论是否处理，所有牙根对细胞活力均无任何显著不良影响。然而，只有经过根面平整的牙根，无论是否使用柠檬酸，都能促进细胞附着和生长。
