Shkhvatsabaia I K, Ustinova S E, Uchitel' I A, Chikhladze N M, Patrusheva I F
Kardiologiia. 1983 Apr;23(4):5-10.
Renin-aldosterone function was studied in 23 patients with low-renin essential hypertension (LREH) under resting and stimulated conditions. Patients were selected on the basis of differential diagnostic tests of renin-angiotensin stimulation and inhibition as well as roentgeno-radiologic findings in order to rule out adrenal lesions. The results were compared with those of patients with primary aldosteronism and with essential hypertension where renin activity can be stimulated under similar sodium balance conditions. Intravenous or prolonged furosemide administration was shown to be the test of choice for the diagnosis of renin suppression. The renin-aldosterone system of LREH patients featured subnormal renin activity and normal aldosterone levels in baseline conditions, and the lack of renin stimulation together with limited aldosterone stimulation following functional tests. The analysis of changes in diuresis, natriuresis and the pattern of Na/K coefficient points to a great diuretic and natriuretic effect of furosemide in patients with LREH.
在静息和刺激条件下，对23例低肾素性原发性高血压（LREH）患者的肾素-醛固酮功能进行了研究。根据肾素-血管紧张素刺激和抑制的鉴别诊断试验以及X线放射学检查结果选择患者，以排除肾上腺病变。将结果与原发性醛固酮增多症患者以及在相似钠平衡条件下肾素活性可被刺激的原发性高血压患者的结果进行比较。静脉注射或长期给予速尿被证明是诊断肾素抑制的首选试验。LREH患者的肾素-醛固酮系统在基线条件下表现为肾素活性低于正常，醛固酮水平正常，功能试验后缺乏肾素刺激以及醛固酮刺激有限。对利尿、利钠以及钠/钾系数模式变化的分析表明，速尿对LREH患者具有显著的利尿和利钠作用。
