Liu G, Coulston A, Chen Y D, Reaven G M
Metabolism. 1983 Aug;32(8):754-6. doi: 10.1016/0026-0495(83)90104-x.
Plasma glucose and insulin responses to a standard oral glucose tolerance test (75 g of glucose) and to mixed meals were compared in 15 normal subjects and 15 patients with non-insulin-dependent diabetes mellitus (NIDDM). Fasting plasma glucose levels were above 140 mg/dL in all patients with NIDDM, and the two groups were weight matched. Plasma glucose levels were significantly higher in patients with NIDDM throughout the glucose tolerance test, and this was associated with a marked reduction in plasma insulin response. Plasma glucose levels were also higher in patients with NIDDM when measured hourly from 8 AM to 5 PM (mixed meals were consumed at 8 AM and 12 PM), but the plasma insulin concentration of the two groups were similar. Thus, the day-long circulating insulin levels of patients with NIDDM are not reduced. Consequently, these patients cannot be considered to be absolutely insulin deficient.
对15名正常受试者和15名非胰岛素依赖型糖尿病（NIDDM）患者进行了比较，观察他们对标准口服葡萄糖耐量试验（75克葡萄糖）和混合餐的血浆葡萄糖及胰岛素反应。所有NIDDM患者的空腹血浆葡萄糖水平均高于140毫克/分升，且两组体重匹配。在整个葡萄糖耐量试验中，NIDDM患者的血浆葡萄糖水平显著更高，且这与血浆胰岛素反应的明显降低相关。从上午8点到下午5点每小时测量一次时，NIDDM患者的血浆葡萄糖水平也更高（上午8点和中午12点进食混合餐），但两组的血浆胰岛素浓度相似。因此，NIDDM患者全天的循环胰岛素水平并未降低。所以，不能认为这些患者绝对缺乏胰岛素。
