Gray R S, Irvine W J, Cameron E H, Duncan L J
Diabetes. 1980 Apr;29(4):312-6. doi: 10.2337/diab.29.4.312.
Plasma insulin, glucose, and insulin/glucose responses to a 50-g oral glucose tolerance test (OGTT) were compared in 14 islet cell antibody (ICAb) positive non-insulin-dependent diabetics (NIDDM), 14 matched ICAb negative NIDDM, and 14 ICAb negative nondiabetic controls. Both groups of NIDDM exhibited marked carbohydrate intolerance with insulinopenia. Despite having significantly higher plasma glucose concentrations during the study, the ICAb positive NIDDM had significantly lower insulin levels, and thus lower insulin/glucose ratios, than the ICAb negative NIDDM both in the fasting state and in response to the OGTT. Similarily, ICAb positive NIDDM had higher integrated glucose responses (delta G), lower integrated insulin responses (delta I), and lower delta I/delta G values than ICAb negative NIDDM. Three ICAb negative and seven ICAb positive NIDDM subsequently required insulin treatment. These findings show that ICAb positive NIDDM suffer from a greater disturbance of B-cell function than do matched ICAb negative NIDDM.
对14名胰岛细胞抗体（ICAb）阳性的非胰岛素依赖型糖尿病患者（NIDDM）、14名匹配的ICAb阴性的NIDDM患者以及14名ICAb阴性的非糖尿病对照者，比较了他们在口服50克葡萄糖耐量试验（OGTT）时的血浆胰岛素、葡萄糖及胰岛素/葡萄糖反应。两组NIDDM患者均表现出明显的碳水化合物不耐受及胰岛素分泌减少。尽管在研究期间ICAb阳性的NIDDM患者血浆葡萄糖浓度显著更高，但无论是在空腹状态还是对OGTT的反应中，其胰岛素水平均显著低于ICAb阴性的NIDDM患者，因此胰岛素/葡萄糖比值也更低。同样，ICAb阳性的NIDDM患者的葡萄糖综合反应（ΔG）更高，胰岛素综合反应（ΔI）更低，且ΔI/ΔG值低于ICAb阴性的NIDDM患者。随后，3名ICAb阴性和7名ICAb阳性的NIDDM患者需要胰岛素治疗。这些发现表明，与匹配的ICAb阴性的NIDDM患者相比，ICAb阳性的NIDDM患者的胰岛B细胞功能受到的干扰更大。
