Maron R, Elias D, de Jongh B M, Bruining G J, van Rood J J, Shechter Y, Cohen I R
Nature. 1983 Jun 30;303(5920):817-8. doi: 10.1038/303817a0.
Insulin-dependent diabetes mellitus (IDDM) usually begins in childhood or early adulthood, and its aetiology is thought to involve autoimmune damage to the islet cells that secrete insulin. To investigate an additional target of autoimmunity in IDDM we examined sera for antibodies to insulin receptors. Such antibodies were defined by their ability to compete with insulin for binding to insulin receptors and by their capacity to behave like insulin in activating lipogenesis in adipocytes. We now report the occurrence of anti-insulin receptor antibodies of the IgM class in the sera of 10 of 22 IDDM patients obtained before their treatment with exogenous insulin. Furthermore, two of five IDDM patients who were initially negative developed anti-insulin receptor antibodies during treatment with human or pork insulin. These findings suggest that autoimmunity to the insulin receptor may contribute to the pathophysiology of IDDM.
胰岛素依赖型糖尿病（IDDM）通常始于儿童期或成年早期，其病因被认为涉及对分泌胰岛素的胰岛细胞的自身免疫损伤。为了研究IDDM中自身免疫的另一个靶点，我们检测了血清中胰岛素受体抗体。此类抗体通过其与胰岛素竞争结合胰岛素受体的能力以及在激活脂肪细胞脂肪生成中表现得像胰岛素的能力来定义。我们现在报告，在22例IDDM患者中，有10例在接受外源性胰岛素治疗前的血清中出现了IgM类抗胰岛素受体抗体。此外，最初为阴性的5例IDDM患者中有2例在用人胰岛素或猪胰岛素治疗期间产生了抗胰岛素受体抗体。这些发现表明，对胰岛素受体的自身免疫可能在IDDM的病理生理过程中起作用。
