Donat H, Morenz J
Zentralbl Gynakol. 1983;105(8):493--503.
Sera from 150 infertile and 50 fertile couples were examined for circulating anti-genital organ antibodies by indirect immunofluorescence test on unfixed cryostat sections from various organs and methanolfixed smears of spermatozoa. -- Antibodies to spermatozoa showed an acrosomal, equatorial, postnuclear or tail immunofluorescence pattern. -- Antibodies to the ovary were directed to theca folliculi and to stromal antigens. Antibodies to the Fallopian tube reacted with the apical parts of the epithelial cells. Antibodies to endometrium and cervix were directed to glandular epithelium or mucosal stroma and antibodies to placenta reacted with trophoblast cells or amnion epithelium. Testicular antibodies were directed to tunica propria or the germinal epithelium. -- Antibodies to epididymis stained the mucous membrane epithelium, basal cells, the tunica propria or epididymal spermatozoa. Antibodies to the prostate and seminal vesicles reacted with glandular epithelium or stroma. -- Autoimmune mechanisms may play diverse roles in the pathogenesis of dysfunction of female and male genital organs.
通过对来自不同器官的未固定低温恒温器切片以及甲醇固定的精子涂片进行间接免疫荧光试验，检测了150对不育夫妇和50对可育夫妇血清中的循环抗生殖器官抗体。——抗精子抗体呈现顶体、赤道、核后或尾部免疫荧光模式。——抗卵巢抗体针对卵泡膜和基质抗原。抗输卵管抗体与上皮细胞的顶端部分发生反应。抗子宫内膜和抗宫颈抗体针对腺上皮或黏膜基质，抗胎盘抗体与滋养层细胞或羊膜上皮发生反应。抗睾丸抗体针对固有膜或生精上皮。——抗附睾抗体使黏膜上皮、基底细胞、固有膜或附睾精子染色。抗前列腺和精囊抗体与腺上皮或基质发生反应。——自身免疫机制可能在女性和男性生殖器官功能障碍的发病机制中发挥多种作用。
