Ives J C, Buffler P A, Greenberg S D
Am Rev Respir Dis. 1983 Jul;128(1):195-209. doi: 10.1164/arrd.1983.128.1.195.
An update of histopathologic classification schemes is provided for carcinoma of the lung and factors that influence proportional distributions of cell types, i.e., sources and preparations of tissue specimens, observer variability, and use of secondary sources of information. Consideration is given to the natural history and to current knowledge of the demographic characteristics of cell types of carcinoma of the lung. A review of studies reporting histopathologic associations with environmental exposures suggests that no single type of carcinoma of the lung is specifically associated with exposure to tobacco smoke, arsenic, or beryllium. Furthermore, studies concerned with exposure to asbestos, chloroethers, chromates, nickel, vinyl chloride, and radioactivity lack sufficient information to conclude definitively that only one specific lung cancer cell type is associated with these exposures. In conclusion, an exclusive association of a single cell type of carcinoma of the lung with exposure to the physical or chemical agents reviewed has not been demonstrated.
本文提供了肺癌组织病理学分类方案的更新内容，以及影响细胞类型比例分布的因素，即组织标本的来源和制备、观察者的变异性，以及辅助信息来源的使用情况。同时考虑了肺癌的自然病史和目前关于肺癌细胞类型人口统计学特征的知识。对报告组织病理学与环境暴露关联的研究进行综述表明，没有单一类型的肺癌与接触烟草烟雾、砷或铍有特定关联。此外，关于接触石棉、氯醚、铬酸盐、镍、氯乙烯和放射性物质的研究缺乏足够信息来明确得出只有一种特定的肺癌细胞类型与这些暴露有关的结论。总之，尚未证明肺癌的单一细胞类型与所审查的物理或化学物质暴露之间存在排他性关联。
