Tsonis P A
Anticancer Res. 1983 May-Jun;3(3):195-202.
The effects of chemical carcinogens on regenerating and non-regenerating limbs in amphibia are reviewed. The regeneration-competent tissues show a remarkable resistance to chemical carcinogenesis. However, chemical carcinogens can induce teratogenesis when they are administered to the regeneration blastema, while normal differentiation occurs in limited cases when they are administered to the intact limbs. The regenerative capacity may be considered as the deterrent to neoplasia in these tissues.
本文综述了化学致癌物对两栖动物再生和非再生肢体的影响。具有再生能力的组织对化学致癌作用表现出显著的抗性。然而，当将化学致癌物施用于再生芽基时，它们可诱导致畸，而当将其施用于完整肢体时，在有限的情况下会发生正常分化。再生能力可被视为这些组织中肿瘤形成的抑制因素。
