肿瘤抑制因子：促进还是抑制再生？
Tumor suppressors: enhancers or suppressors of regeneration?
机构信息
Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California, San Francisco, CA 94143, USA.
出版信息
Development. 2013 Jun;140(12):2502-12. doi: 10.1242/dev.084210.
Abstract
Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essential for tissue regeneration. This is in contrast to suggestions that tumor suppression is a trade-off for regenerative capacity. We also hypothesize that certain aspects of tumor suppressor pathways inhibit regenerative processes in mammals, and that transient targeted modification of these pathways could be fruitfully exploited to enhance processes that are important to regenerative medicine.
摘要
肿瘤抑制因子之所以被命名为肿瘤抑制因子，是因为在它们缺失的情况下会发生癌症，但这些基因在发育、代谢和组织稳态中也具有重要功能。在这里，我们讨论了在组织再生过程中已知和潜在的肿瘤抑制基因的功能，重点是进化上保守的肿瘤抑制因子 pRb1、p53、Pten 和 Hippo。我们提出，它们的活性对于组织再生是必不可少的。这与肿瘤抑制是再生能力的权衡的观点相反。我们还假设，肿瘤抑制途径的某些方面抑制了哺乳动物的再生过程，并且这些途径的短暂靶向修饰可以有效地用于增强对再生医学很重要的过程。
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