Robertson W H
Am J Obstet Gynecol. 1978 Oct 1;132(3):321-3. doi: 10.1016/0002-9378(78)90900-6.
Clotrimazole 1 per cent vaginal cream administered daily over a seven-day period was compared with miconazole nitrate 2 per cent vaginal cream administered daily over a 14 day period for the treatment of vulvovaginal candidiasis in a double-blind study of 65 women with clinical symptoms of this condition,, for whom treatment was randomly allocated. When efficacy of treatment was evaluated in 44 of these patients, a success rate, based on both clinical and mycologic criteria, of 75 per cent was found in the 20 patients treated with clotrimazole for seven days as compared with a 63 per cent success rate in the 24 patients treated with miconazole for 14 days. Of the 65 women enrolled in the study, two of the miconazole-treated patients experienced burning sensations, whereas the clotrimazole-treated patients experienced no adverse reactions. Thus, in this group of patients clotrimazole 1 per cent vaginal cream was shown to have a slightly, but not significantly, better efficacy than the miconazole nitrate 2 per cent vaginal cream, with no adverse reactions and in half the treatment time.
在一项针对65名有外阴阴道念珠菌病临床症状的女性的双盲研究中，将1%克霉唑阴道乳膏每日给药，持续7天，与2%硝酸咪康唑阴道乳膏每日给药，持续14天进行比较，这些患者的治疗是随机分配的。当对其中44名患者的治疗效果进行评估时，基于临床和真菌学标准，在接受7天克霉唑治疗的20名患者中，成功率为75%，而在接受14天硝酸咪康唑治疗的24名患者中，成功率为63%。在参与研究的65名女性中，两名接受硝酸咪康唑治疗的患者出现烧灼感，而接受克霉唑治疗的患者未出现不良反应。因此，在这组患者中，1%克霉唑阴道乳膏显示出比2%硝酸咪康唑阴道乳膏有稍好但无显著差异的疗效，且无不良反应，治疗时间缩短一半。
