DeMonaco H J, McGovern B
Drug Intell Clin Pharm. 1983 Jul-Aug;17(7-8):547-8. doi: 10.1177/106002808301700711.
Amphotericin B, a systemic antifungal agent, has not been associated with clinical evidence of cardiac toxicity. We report the case of a 76-year-old patient who developed transient asystole with cardiovascular collapse on two occasions, which coincided with infusion of amphotericin B. The patient was semicomatose and had candida septicemia and renal failure. Serum potassium and digoxin levels were elevated, and serum calcium was low when these episodes occurred. Subsequent postmortem examination revealed no gross evidence of cardiac disease apart from fungal vegetations on the aortic valve. A clear causal relationship between amphotericin B and transient asystole is not demonstrated, but a temporal association, confirmed with rechallenge, is documented in this patient. No similar cases were found in a review of the literature.
两性霉素B是一种全身性抗真菌药，尚无心脏毒性的临床证据。我们报告一例76岁患者，两次在输注两性霉素B时出现短暂心脏停搏并伴有心血管虚脱。患者处于半昏迷状态，患有念珠菌败血症和肾衰竭。这些发作发生时，血清钾和地高辛水平升高，血清钙水平降低。随后的尸检显示，除主动脉瓣上有真菌赘生物外，无明显心脏病证据。虽然未证实两性霉素B与短暂心脏停搏之间存在明确的因果关系，但该患者有时间上的关联，并通过再次激发得到证实。文献回顾中未发现类似病例。
