Thakur C P
Natl Med J India. 1995 Jan-Feb;8(1):13-4.
Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them. I saw two patients with kala-azar resistant to sodium stibogluconate who developed cardiac arrest after amphotericin infusion (in spite of tolerating a test dose). Both had low levels of serum sodium, potassium and calcium. After these were corrected the amphotericin B was restarted and the course of treatment completed successfully. I suggest that prior to giving amphotericin B to patients with resistant kala-azar their electrolyte imbalance should be corrected.
在使用两性霉素B的过程中曾有过心律失常和心脏骤停的报道，但尚未有有效的预防技术被描述。我见过两名对葡萄糖酸锑钠耐药的黑热病患者，他们在输注两性霉素后发生了心脏骤停（尽管耐受了试验剂量）。两人的血清钠、钾和钙水平均较低。在纠正这些电解质紊乱后，重新开始使用两性霉素B并成功完成了治疗疗程。我建议，在给耐药黑热病患者使用两性霉素B之前，应纠正其电解质失衡。
