Binding of immunoglobulins to protein A and immunoglobulin levels in mammalian sera.

The use of protein A from S. aureus (SpA) as an anti-IgG reagent in immunological techniques has extended in recent years, together with knowledge about its interaction with immunoglobulins of different species. Current data with respect to the binding of protein A to immunoglobulins and to the levels of immunoglobulins in the sera of some mammalian species are reviewed.