Tsuchiya T, Yamaha T
J Toxicol Sci. 1983 Feb;8(1):15-24. doi: 10.2131/jts.8.15.
When mice were fed on a diet containing 15% sorbic acid for a period up to 6 months, ether extracts of the intestinal contents of the mice were not mutagenic with Salmonella typhimurium TA98, but the acidic components obtained by fractionating the ether extracts, showed slightly mutagenic activity with S. typhimurium TA98, and they required the addition of liver 9,000 xg supernatant fraction for mutagenic activation. These results suggested that mutagens were gradually produced in the intestine and moved into the liver where they were metabolically activated. It is possible to presume that liver carcinoma might be attributable to the production of these mutagens.
当给小鼠喂食含15%山梨酸的饮食长达6个月时，小鼠肠道内容物的乙醚提取物对鼠伤寒沙门氏菌TA98无致突变性，但将乙醚提取物分级分离得到的酸性成分对鼠伤寒沙门氏菌TA98显示出轻微的致突变活性，且它们需要添加肝脏9000xg上清液组分才能进行致突变激活。这些结果表明，诱变剂在肠道中逐渐产生并进入肝脏，在肝脏中它们被代谢激活。可以推测，肝癌可能归因于这些诱变剂的产生。
