Docci D, Turci F, Salvi G
Nephron. 1983;34(3):198-200. doi: 10.1159/000183010.
Idiopathic edema is a condition characterized by diurnal weight gain and intermittent swelling, affecting adult females without evidence of any other condition known to cause sodium retention. It has been suggested that an alteration in the aldosterone response to upright posture plays a pathogenetic role in orthostatic sodium and water retention peculiar to this syndrome. To test this hypothesis, the effect of captopril was evaluated in 4 women with idiopathic edema. The therapeutic response was impressive in all. In summary, we noted a remarkable decrease in morning to evening weight difference, an increase in both diuresis and natriuresis, and a definite symptomatic improvement. It is therefore possible to speculate that captopril, by reversing the basic abnormality acting in idiopathic edema, may prove of benefit in most patients with this peculiar syndrome.
特发性水肿是一种以日间体重增加和间歇性肿胀为特征的病症，影响成年女性，且无已知其他导致钠潴留病症的证据。有人提出，醛固酮对直立姿势反应的改变在该综合征特有的体位性钠和水潴留中起致病作用。为验证这一假说，对4名特发性水肿女性患者评估了卡托普利的疗效。所有人的治疗反应都令人印象深刻。总之，我们注意到早晚体重差异显著减小，利尿和利钠均增加，且症状有明确改善。因此可以推测，卡托普利通过逆转特发性水肿中的基本异常情况，可能对大多数患有这种特殊综合征的患者有益。
