Serum and lung tissue levels of fosfomycin in humans.

Fosfomycin levels were determined in the serum and the lung tissue removed during 26 pulmonary operations following intramuscular or intravenous administration of 2 g fosfomycin. In the serum the level was about 32 micrograms/ml 1--2 h subsequent to the administration. At the same time, the removed lung tissue showed 12--16 micrograms/g concentration in the apparently intact parts, amounting to 32--52% of the serum level, whereas in the tumorous lung tissue roughly half of this concentration was present. The fosfomycin levels found in the lung tissue are effective only against a group of bacteria causing respiratory inflammation.