Sirot J, Lopitaux R, Dumont C, Delisle J J, Rampon S, Cluzel R
Pathol Biol (Paris). 1982 Jun;30(6):332-5.
Cloxacillin diffusion into spongious and cortical bone was studied in 20 patients undergoing total replacement of the hip, after an oral single-dose of 1 g (10 patients) or an oral dose of 1 g every 8 hours (10 patients). Serum and bone samples were collected 2 and 3 hours after the last dose and assayed for antibiotic concentration by a microbiological method. Bone levels were similar in any group of patients, but significantly higher in spongious bone than in cortical bone. The bone/serum concentration ratios were 0.15 for spongious bone and 0.10 for cortical bone. Calculations from these data showed that adequate local levels inhibitory to Staphylococcus aureus, would be achieved by cloxacillin administration of 1 g dose every 4 hours orally.
在20例接受全髋关节置换术的患者中，研究了氯唑西林向松质骨和皮质骨的扩散情况。这些患者分为两组，一组单次口服1 g（10例患者），另一组每8小时口服1 g（10例患者）。在最后一剂药物服用后2小时和3小时采集血清和骨样本，采用微生物学方法测定抗生素浓度。任何一组患者的骨浓度相似，但松质骨中的浓度明显高于皮质骨。松质骨的骨/血清浓度比为0.15，皮质骨为0.10。根据这些数据计算表明，每4小时口服1 g氯唑西林可达到对金黄色葡萄球菌有抑制作用的足够局部浓度。
