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1
Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens.用两种相关致癌物处理后，大肠杆菌（PQ 10）中RecA蛋白的不同诱导水平。
Nucleic Acids Res. 1983 Aug 11;11(15):5235-42. doi: 10.1093/nar/11.15.5235.
2
Repair and mutagenesis of plasmid DNA modified by ultraviolet irradiation or N-acetoxy-N-2-acetylaminofluorene.紫外线照射或N-乙酰氧基-N-2-乙酰氨基芴修饰的质粒DNA的修复与诱变
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4133-7. doi: 10.1073/pnas.79.13.4133.
3
Cellular strategies for accommodating replication-hindering adducts in DNA: control by the SOS response in Escherichia coli.细胞应对DNA中阻碍复制加合物的策略：大肠杆菌中SOS反应的调控
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7805-10. doi: 10.1073/pnas.93.15.7805.
4
Specificity of N-acetoxy-N-2-acetylaminofluorene-induced frameshift mutation spectrum in mismatch repair deficient Escherichia coli strains mutH, L, S and U.错配修复缺陷型大肠杆菌菌株mutH、L、S和U中N-乙酰氧基-N-2-乙酰氨基芴诱导的移码突变谱的特异性
J Mol Biol. 1986 Aug 5;190(3):499-507. doi: 10.1016/0022-2836(86)90018-5.
5
DNA binding and mutation spectra of the carcinogen N-2-aminofluorene in Escherichia coli. A correlation between the conformation of the premutagenic lesion and the mutation specificity.致癌物质N-2-氨基芴在大肠杆菌中的DNA结合及突变谱。诱变前损伤的构象与突变特异性之间的相关性。
J Mol Biol. 1985 Jun 5;183(3):341-51. doi: 10.1016/0022-2836(85)90005-1.
6
Stimulation of recombination between homologous sequences on plasmid DNA and chromosomal DNA in Escherichia coli by N-acetoxy-2-acetylaminofluorene.N-乙酰氧基-2-乙酰氨基芴对大肠杆菌中质粒DNA与染色体DNA同源序列间重组的刺激作用。
Proc Natl Acad Sci U S A. 1984 May;81(9):2831-5. doi: 10.1073/pnas.81.9.2831.
7
Genetic control of AAF-induced mutagenesis at alternating GC sequences: an additional role for RecA.在交替的GC序列处AAF诱导的诱变的遗传控制：RecA的另一个作用。
Mol Gen Genet. 1989 Jan;215(2):306-11. doi: 10.1007/BF00339733.
8
Mechanisms for the recognition of chemically-modified DNA by peptides and proteins.肽和蛋白质识别化学修饰DNA的机制。
Biochimie. 1982 Aug-Sep;64(8-9):697-705. doi: 10.1016/s0300-9084(82)80113-2.
9
Ultraviolet light induction of recA protein in a recB uvrB mutant of Escherichia coli.紫外线诱导大肠杆菌recB uvrB突变体中recA蛋白的产生。
J Bacteriol. 1980 Aug;143(2):1025-8. doi: 10.1128/jb.143.2.1025-1028.1980.
10
Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene.多聚（dG-dC）·多聚（dG-dC）的构象：被致癌物N-乙酰氧基-N-乙酰-2-氨基芴和N-羟基-N-2-氨基芴修饰后的情况
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4597-601. doi: 10.1073/pnas.77.8.4597.

引用本文的文献

1
The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.大肠杆菌对烷基化剂氯乙醛和环氧苯乙烷的反应。
Mutat Res Genet Toxicol Environ Mutagen. 2019 Apr;840:1-10. doi: 10.1016/j.mrgentox.2019.02.001. Epub 2019 Feb 7.
2
Mutational spectrum induced in Saccharomyces cerevisiae by the carcinogen N-2-acetylaminofluorene.致癌物 N-2-乙酰氨基芴在酿酒酵母中诱导产生的突变谱。
Mol Gen Genet. 1994 Oct 17;245(1):69-77. doi: 10.1007/BF00279752.
3
pBR322 plasmid DNA modified with 2-acetylaminofluorene derivatives: transforming activity and in vitro strand cleavage by the Escherichia coli uvrABC endonuclease.用2-乙酰氨基芴衍生物修饰的pBR322质粒DNA：转化活性及大肠杆菌uvrABC核酸内切酶的体外链切割
EMBO J. 1984 Apr;3(4):757-60. doi: 10.1002/j.1460-2075.1984.tb01880.x.
4
Measurement of in vivo expression of the recA gene of Escherichia coli by using lacZ gene fusions.利用lacZ基因融合技术测定大肠杆菌recA基因的体内表达
J Bacteriol. 1984 Oct;160(1):112-21. doi: 10.1128/jb.160.1.112-121.1984.
5
uvrC gene function has no specific role in repair of N-2-aminofluorene adducts.uvrC基因功能在N-2-氨基芴加合物的修复中没有特定作用。
J Bacteriol. 1987 Jan;169(1):423-6. doi: 10.1128/jb.169.1.423-426.1987.
6
Base pair substitution and frameshift mutagenesis induced by apurinic sites and two fluorene derivatives in a recA441 lexA (Def) strain.
Mol Gen Genet. 1986 Jan;202(1):90-5. doi: 10.1007/BF00330522.
7
Induction of -2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues: development of a specific mutation assay.通过与鸟嘌呤残基的C8位结合的致癌物在交替GC序列中诱导-2移码突变：一种特异性突变检测方法的开发
Mol Gen Genet. 1990 May;221(3):331-8. doi: 10.1007/BF00259396.
8
Nucleotide excision repair in Escherichia coli.大肠杆菌中的核苷酸切除修复
Microbiol Rev. 1990 Mar;54(1):18-51. doi: 10.1128/mr.54.1.18-51.1990.

本文引用的文献

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Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene.脱氧鸟苷构象对N - 乙酰化和未乙酰化的2 - 氨基芴在C - 8位结合的敏感性。
Carcinogenesis. 1980;1(11):955-9. doi: 10.1093/carcin/1.11.955.
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Structural modification and protein recognition of DNA modified by N-2-fluorenylacetamide, its 7-iodo derivative, and by N-2-fluorenamine.N-2-芴基乙酰胺及其7-碘衍生物以及N-2-芴胺修饰的DNA的结构修饰与蛋白质识别
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The SOS regulatory system of Escherichia coli.大肠杆菌的SOS调控系统。
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An immunoradiometric quantitative assay of Escherichia coli recA protein.
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Induction of recA protein in Escherichia coli by three platinum (II) compounds.三种铂（II）化合物对大肠杆菌中recA蛋白的诱导作用。
Biochem Biophys Res Commun. 1982 Mar 15;105(1):202-8. doi: 10.1016/s0006-291x(82)80031-4.
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Efficiency of Escherichia coli repair processes on uv-damaged transforming plasmid DNA.大肠杆菌对紫外线损伤的转化质粒DNA的修复过程效率
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7
uvr Genes function differently in repair of acetylaminofluorene and aminofluorene DNA adducts.uvr基因在乙酰氨基芴和氨基芴DNA加合物的修复中发挥不同作用。
Nature. 1982 Oct 14;299(5884):646-8. doi: 10.1038/299646a0.
8
Control of UV induction of recA protein.recA蛋白紫外线诱导的调控
Proc Natl Acad Sci U S A. 1983 Jan;80(1):65-9. doi: 10.1073/pnas.80.1.65.
9
Conformation of acetylaminofluorene and aminofluorene modified guanosine and guanosine derivatives.乙酰氨基芴以及氨基芴修饰的鸟苷和鸟苷衍生物的构象。
Biochem Biophys Res Commun. 1980 Oct 16;96(3):1095-102. doi: 10.1016/0006-291x(80)90064-9.
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Interactions between DNA polymerase and aminofluorene adducts that affect the recognition and possibly the mutagenicity of the lesions.DNA聚合酶与氨基芴加合物之间的相互作用，这种相互作用会影响损伤的识别以及可能的致突变性。
Biochimie. 1982 Aug-Sep;64(8-9):757-62. doi: 10.1016/s0300-9084(82)80125-9.

用两种相关致癌物处理后，大肠杆菌（PQ 10）中RecA蛋白的不同诱导水平。

Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens.

作者信息

Salles B, Lang M C, Freund A M, Paoletti C, Daune M, Fuchs R P

出版信息

Nucleic Acids Res. 1983 Aug 11;11(15):5235-42. doi: 10.1093/nar/11.15.5235.

DOI:10.1093/nar/11.15.5235
PMID:6348704
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC326256/
Abstract

By means of an immunoradiometric assay the induction of protein RecA in E. coli PQ 10 was measured after treatment by two related carcinogens. On an adduct basis N-Acetoxy-N-2-acetylaminofluorene was shown to induce the protein RecA at a similar level as U.V. On the other hand, N-hydroxy-N-2-aminofluorene shows only a poor induction capacity of the RecA protein. The difference in the SOS inducing potential of the aminofluorene and acetylaminofluorene adducts is discussed in relation to the major difference in the local conformational change the two adducts induce in DNA.

摘要

通过免疫放射分析，在两种相关致癌物处理后，测定了大肠杆菌PQ 10中RecA蛋白的诱导情况。以加合物为基础，N-乙酰氧基-N-2-乙酰氨基芴诱导RecA蛋白的水平与紫外线相似。另一方面，N-羟基-N-2-氨基芴诱导RecA蛋白的能力较差。讨论了氨基芴和乙酰氨基芴加合物在SOS诱导潜力方面的差异与这两种加合物在DNA中诱导的局部构象变化的主要差异之间的关系。