用两种相关致癌物处理后，大肠杆菌（PQ 10）中RecA蛋白的不同诱导水平。
Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens.
作者信息
Salles B, Lang M C, Freund A M, Paoletti C, Daune M, Fuchs R P
出版信息
Nucleic Acids Res. 1983 Aug 11;11(15):5235-42. doi: 10.1093/nar/11.15.5235.
Abstract
By means of an immunoradiometric assay the induction of protein RecA in E. coli PQ 10 was measured after treatment by two related carcinogens. On an adduct basis N-Acetoxy-N-2-acetylaminofluorene was shown to induce the protein RecA at a similar level as U.V. On the other hand, N-hydroxy-N-2-aminofluorene shows only a poor induction capacity of the RecA protein. The difference in the SOS inducing potential of the aminofluorene and acetylaminofluorene adducts is discussed in relation to the major difference in the local conformational change the two adducts induce in DNA.
摘要
通过免疫放射分析，在两种相关致癌物处理后，测定了大肠杆菌PQ 10中RecA蛋白的诱导情况。以加合物为基础，N-乙酰氧基-N-2-乙酰氨基芴诱导RecA蛋白的水平与紫外线相似。另一方面，N-羟基-N-2-氨基芴诱导RecA蛋白的能力较差。讨论了氨基芴和乙酰氨基芴加合物在SOS诱导潜力方面的差异与这两种加合物在DNA中诱导的局部构象变化的主要差异之间的关系。
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