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1
Repair and mutagenesis of plasmid DNA modified by ultraviolet irradiation or N-acetoxy-N-2-acetylaminofluorene.紫外线照射或N-乙酰氧基-N-2-乙酰氨基芴修饰的质粒DNA的修复与诱变
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4133-7. doi: 10.1073/pnas.79.13.4133.
2
Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coli. Strain specificity and mutation-prone sequences.致癌物诱导的大肠杆菌野生型、uvrA和umuC菌株中的突变谱。菌株特异性和易突变序列。
J Mol Biol. 1984 Jul 25;177(1):33-51. doi: 10.1016/0022-2836(84)90056-1.
3
Specificity of N-acetoxy-N-2-acetylaminofluorene-induced frameshift mutation spectrum in mismatch repair deficient Escherichia coli strains mutH, L, S and U.错配修复缺陷型大肠杆菌菌株mutH、L、S和U中N-乙酰氧基-N-2-乙酰氨基芴诱导的移码突变谱的特异性
J Mol Biol. 1986 Aug 5;190(3):499-507. doi: 10.1016/0022-2836(86)90018-5.
4
Stimulation of recombination between homologous sequences on plasmid DNA and chromosomal DNA in Escherichia coli by N-acetoxy-2-acetylaminofluorene.N-乙酰氧基-2-乙酰氨基芴对大肠杆菌中质粒DNA与染色体DNA同源序列间重组的刺激作用。
Proc Natl Acad Sci U S A. 1984 May;81(9):2831-5. doi: 10.1073/pnas.81.9.2831.
5
pBR322 plasmid DNA modified with 2-acetylaminofluorene derivatives: transforming activity and in vitro strand cleavage by the Escherichia coli uvrABC endonuclease.用2-乙酰氨基芴衍生物修饰的pBR322质粒DNA：转化活性及大肠杆菌uvrABC核酸内切酶的体外链切割
EMBO J. 1984 Apr;3(4):757-60. doi: 10.1002/j.1460-2075.1984.tb01880.x.
6
Direct comparison, in humans resting lymphocytes, of the inter-individual variations in unscheduled DNA synthesis induced by N-acetoxy-2-acetylaminofluorene and ultraviolet irradiation.对N-乙酰氧基-2-乙酰氨基芴和紫外线照射诱导的人静止淋巴细胞中DNA非定标合成的个体间差异进行直接比较。
Mutat Res. 1980 Dec;73(2):349-61. doi: 10.1016/0027-5107(80)90200-6.
7
Mutational and recombinational events in carcinogen-modified plasmid DNA. Influence of host-cell repair genes.致癌物修饰质粒DNA中的突变和重组事件。宿主细胞修复基因的影响。
Mutat Res. 1985 Jan-Mar;145(1-2):25-34. doi: 10.1016/0167-8817(85)90036-7.
8
Genetic control of AAF-induced mutagenesis at alternating GC sequences: an additional role for RecA.在交替的GC序列处AAF诱导的诱变的遗传控制：RecA的另一个作用。
Mol Gen Genet. 1989 Jan;215(2):306-11. doi: 10.1007/BF00339733.
9
Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens.用两种相关致癌物处理后，大肠杆菌（PQ 10）中RecA蛋白的不同诱导水平。
Nucleic Acids Res. 1983 Aug 11;11(15):5235-42. doi: 10.1093/nar/11.15.5235.
10
Biochemical analysis of UV mutagenesis in Escherichia coli by using a cell-free reaction coupled to a bioassay: identification of a DNA repair-dependent, replication-independent pathway.利用与生物测定偶联的无细胞反应对大肠杆菌紫外线诱变进行生化分析：鉴定一种依赖DNA修复、不依赖复制的途径。
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3300-4. doi: 10.1073/pnas.89.8.3300.

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Recombination Mediator Proteins: Misnomers That Are Key to Understanding the Genomic Instabilities in Cancer.重组介体蛋白：误解之名，却是理解癌症基因组不稳定性的关键。
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Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions.细菌中依赖 Rho 的转录终止可使在 DNA 损伤处暂停的 RNA 聚合酶重新启动。
Nat Commun. 2019 Mar 14;10(1):1207. doi: 10.1038/s41467-019-09146-5.
3
Inefficient replication reduces RecA-mediated repair of UV-damaged plasmids introduced into competent Escherichia coli.低效复制会降低 RecA 介导的修复紫外线损伤的质粒引入到感受态大肠杆菌。
Plasmid. 2012 Sep;68(2):113-24. doi: 10.1016/j.plasmid.2012.04.002. Epub 2012 Apr 19.
4
Cellular strategies for accommodating replication-hindering adducts in DNA: control by the SOS response in Escherichia coli.细胞应对DNA中阻碍复制加合物的策略：大肠杆菌中SOS反应的调控
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7805-10. doi: 10.1073/pnas.93.15.7805.
5
Temporal distinction between repair and mutagenesis of benzopyrene adducts after SOS induction in Escherichia coli.大肠杆菌SOS诱导后苯并芘加合物修复与诱变的时间差异。
J Bacteriol. 1983 Nov;156(2):926-30. doi: 10.1128/jb.156.2.926-930.1983.
6
pBR322 plasmid DNA modified with 2-acetylaminofluorene derivatives: transforming activity and in vitro strand cleavage by the Escherichia coli uvrABC endonuclease.用2-乙酰氨基芴衍生物修饰的pBR322质粒DNA：转化活性及大肠杆菌uvrABC核酸内切酶的体外链切割
EMBO J. 1984 Apr;3(4):757-60. doi: 10.1002/j.1460-2075.1984.tb01880.x.
7
Stimulation of recombination between homologous sequences on plasmid DNA and chromosomal DNA in Escherichia coli by N-acetoxy-2-acetylaminofluorene.N-乙酰氧基-2-乙酰氨基芴对大肠杆菌中质粒DNA与染色体DNA同源序列间重组的刺激作用。
Proc Natl Acad Sci U S A. 1984 May;81(9):2831-5. doi: 10.1073/pnas.81.9.2831.
8
Directed mutagenesis method for analysis of mutagen specificity: application to ultraviolet-induced mutagenesis.用于分析诱变特异性的定向诱变方法：应用于紫外线诱导的诱变
Proc Natl Acad Sci U S A. 1983 Jan;80(1):237-41. doi: 10.1073/pnas.80.1.237.
9
Rearrangement and mutagenesis of a shuttle vector plasmid after passage in mammalian cells.穿梭载体质粒在哺乳动物细胞中传代后的重排与诱变
Proc Natl Acad Sci U S A. 1983 May;80(10):3010-4. doi: 10.1073/pnas.80.10.3010.
10
Error-prone mutagenesis detected in mammalian cells by a shuttle vector containing the supF gene of Escherichia coli.通过含有大肠杆菌supF基因的穿梭载体在哺乳动物细胞中检测到易错诱变。
Mol Cell Biol. 1984 Oct;4(10):2227-30. doi: 10.1128/mcb.4.10.2227-2230.1984.

本文引用的文献

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Induction of Mutations in a Bacterial Virus.细菌病毒中突变的诱导
Proc Natl Acad Sci U S A. 1953 Jul;39(7):628-36. doi: 10.1073/pnas.39.7.628.
2
[INFLUENCE OF BACTERIAL HOST GENOTYPE ON LAMBDA PHAGE MUTATION PRODUCED BY ULTRAVIOLET RADIATION].[细菌宿主基因型对紫外线诱导的λ噬菌体突变的影响]
C R Hebd Seances Acad Sci. 1965 Feb 1;260:1510-3.
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The interaction of phage S13 with ultraviolet-irradiated host cells and properties of the ultraviolet-irradiated phage.噬菌体S13与紫外线照射的宿主细胞的相互作用以及紫外线照射噬菌体的特性。
Virology. 1960 Nov;12:431-49. doi: 10.1016/0042-6822(60)90165-3.
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[Mutation of bacteriophage induced by irradiation of bacterial host alone before infection].[感染前仅对细菌宿主进行辐照诱导的噬菌体突变]
C R Hebd Seances Acad Sci. 1954 Feb 8;238(6):732-4.
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A transversion mutation hypothesis for chemical carcinogenesis by N2-substitution of guanine in DNA.关于DNA中鸟嘌呤N2位取代导致化学致癌作用的颠换突变假说。
Chem Biol Interact. 1980 Sep;31(3):255-63. doi: 10.1016/0009-2797(80)90014-9.
6
Hot spots of frameshift mutations induced by the ultimate carcinogen N-acetoxy-N-2-acetylaminofluorene.由终极致癌物N-乙酰氧基-N-2-乙酰氨基芴诱导的移码突变热点。
Nature. 1981 Dec 17;294(5842):657-9. doi: 10.1038/294657a0.
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Radiation-induced base substitution mutagenesis in single-stranded DNA phage M13.辐射诱导单链DNA噬菌体M13中的碱基替换诱变
Nature. 1981 Nov 12;294(5837):180-2. doi: 10.1038/294180a0.
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Efficiency of Escherichia coli repair processes on uv-damaged transforming plasmid DNA.大肠杆菌对紫外线损伤的转化质粒DNA的修复过程效率
Plasmid. 1981 Mar;5(2):213-20. doi: 10.1016/0147-619x(81)90022-6.
9
Differential mutagenicities of 6 N-nitroso-N-alkylurea derivatives in Escherichia coli strains with different DNA-repair capacities.6种N-亚硝基-N-烷基脲衍生物在具有不同DNA修复能力的大肠杆菌菌株中的诱变差异。
Mutat Res. 1980 Dec;79(4):319-25. doi: 10.1016/0165-1218(80)90155-x.
10
Genetic factors in Escherichia coli that affect cell killing and mutagenesis induced by benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide.大肠杆菌中影响苯并(a)芘-7,8-二氢二醇9,10-环氧化物诱导的细胞杀伤和诱变的遗传因素。
Cancer Res. 1980 Oct;40(10):3508-11.

紫外线照射或N-乙酰氧基-N-2-乙酰氨基芴修饰的质粒DNA的修复与诱变

Repair and mutagenesis of plasmid DNA modified by ultraviolet irradiation or N-acetoxy-N-2-acetylaminofluorene.

作者信息

Schmid S E, Daune M P, Fuchs R P

出版信息

Proc Natl Acad Sci U S A. 1982 Jul;79(13):4133-7. doi: 10.1073/pnas.79.13.4133.

DOI:10.1073/pnas.79.13.4133
PMID:7051005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC346591/
Abstract

Plasmid DNA was modified in vitro to various extents with N-acetoxy-N-2-acetylaminofluorene or UV irradiation. The modified plasmid DNAs were then used to transform Escherichia coli strains having different repair capabilities. Both survival and mutagenesis frequencies of the plasmid were measured as a function of the number of lesions per plasmid molecule. The majority of N-2-acetylaminofluorene (AAF) adducts, like thymine dimers, were repaired by the excision (uvrA+-dependent) pathway. In rec+ strains, dose-dependent mutagenesis occurred in either AAF- or UV-modified plasmid DNA. This is in contrast with results obtained in recA- strains, in which only AAF adducts gave rise to a lower, but dose-dependent, mutagenesis frequency. In these recA- strains there was no UV mutagenesis. Unlike what is observed with phages, induction of the "SOS" functions by UV irradiation of the bacteria prior to transformation did not increase the survival or the mutagenesis of the plasmid.

摘要

用N-乙酰氧基-N-2-乙酰氨基芴或紫外线照射对质粒DNA进行不同程度的体外修饰。然后用修饰后的质粒DNA转化具有不同修复能力的大肠杆菌菌株。测定质粒的存活率和诱变频率与每个质粒分子损伤数的函数关系。大多数N-2-乙酰氨基芴（AAF）加合物，如胸腺嘧啶二聚体，通过切除（依赖uvrA+）途径进行修复。在rec+菌株中，AAF或紫外线修饰的质粒DNA中均发生剂量依赖性诱变。这与recA-菌株中获得的结果相反，在recA-菌株中，只有AAF加合物产生较低但剂量依赖性的诱变频率。在这些recA-菌株中没有紫外线诱变。与噬菌体不同，在转化前对细菌进行紫外线照射诱导“SOS”功能并不会增加质粒的存活率或诱变率。