Fairfield A S, Meshnick S R, Eaton J W
Science. 1983 Aug 19;221(4612):764-6. doi: 10.1126/science.6348944.
Aerobic organisms depend on superoxide dismutase to suppress the formation of dangerous species of activated oxygen. Intraerythrocytic stages of the malaria parasite exist within a highly aerobic environment and cause the generation of increased amounts of activated oxygen. Plasmodium berghei in mice was found to derive a substantial amount of superoxide dismutase activity from the host cell cytoplasm. Plasmodia isolated from mouse red cells contained mouse superoxide dismutase, whereas rat-derived parasites contained the rat enzyme. This is believed to be the first example of the acquisition of a host cell enzyme by an intracellular parasite.
需氧生物依靠超氧化物歧化酶来抑制活性氧危险物种的形成。疟原虫的红细胞内期存在于高度需氧的环境中，并导致活性氧生成量增加。研究发现，小鼠体内的伯氏疟原虫从宿主细胞质中获得了大量超氧化物歧化酶活性。从小鼠红细胞中分离出的疟原虫含有小鼠超氧化物歧化酶，而从大鼠体内分离出的疟原虫则含有大鼠的这种酶。这被认为是细胞内寄生虫获取宿主细胞酶的首个实例。
