Smith B R, LeFrock J L
Ther Drug Monit. 1983 Jun;5(2):149-60.
The antimicrobial activity, pharmacology, toxicity, and clinical efficacy of cefuroxime are reviewed. Cefuroxime has a second-generation cephalosporin spectrum of activity similar to cefamandole. Addition of a methoxyimino side chain has enhanced its beta-lactamase stability. Cefuroxime is active against certain cephalothin-, cefamandole-, and gentamicin-resistant bacteria. Cefuroxime has an extended half-life which allows dosing every 8 h. If penetrates into bodily tissues and fluids, including the cerebrospinal fluid, in therapeutic concentrations. Cefuroxime has been used successfully in the treatment of meningitis; sepsis; urinary tract, bone and joint, pulmonary, skin, and soft tissue infections; and gonorrhea. Competitive pricing of cefuroxime should provide a cost-effective substitute for cefamandole and, in certain situations, third-generation cephalosporins.
对头孢呋辛的抗菌活性、药理学、毒性及临床疗效进行综述。头孢呋辛具有与头孢孟多相似的第二代头孢菌素活性谱。甲氧基肟侧链的添加增强了其对β-内酰胺酶的稳定性。头孢呋辛对某些对头孢噻吩、头孢孟多和庆大霉素耐药的细菌有活性。头孢呋辛半衰期延长，允许每8小时给药一次。它能以治疗浓度渗透到身体组织和体液中，包括脑脊液。头孢呋辛已成功用于治疗脑膜炎、败血症、尿路感染、骨与关节感染、肺部感染、皮肤和软组织感染以及淋病。头孢呋辛具有竞争力的价格应能为头孢孟多及在某些情况下为第三代头孢菌素提供一种具有成本效益的替代药物。
