伯氏疟原虫红细胞外期在肝癌细胞系中的体外培养。
In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line.
作者信息
Hollingdale M R, Leland P, Schwartz A L
出版信息
Am J Trop Med Hyg. 1983 Jul;32(4):682-4. doi: 10.4269/ajtmh.1983.32.682.
PMID:6349397
Abstract
When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of the exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.
摘要
用人源肝癌细胞系（HepG2-A16）接种伯氏疟原虫的子孢子后，该细胞系可支持疟原虫在肝细胞内完成整个红细胞外期的无性发育周期。结果显示，该寄生虫与肝细胞内的体内寄生虫相似。将裂殖子再次接种到小鼠体内可引发红细胞感染。
Zotero 插件