Schulz B, Greenfield M, Reaven G M
Exp Clin Endocrinol. 1983 May;81(3):273-9. doi: 10.1055/s-0029-1210236.
We studied the insulin binding to erythrocytes during a 24-h period in 11 normal subjects. Compared with 0800 and 1600 h the specific 125I-insulin binding decreased significantly at midnight. These changes were mainly due to alterations in insulin binding affinity rather than a decrease in receptor number. An inverse finding was obtained concerning the plasma insulin levels. In fact, the highest insulin concentrations were observed at midnight. The results suggest that diurnal variations in insulin receptor function occur in response to fluctuations of plasma insulin levels.
我们在11名正常受试者中研究了24小时内胰岛素与红细胞的结合情况。与08:00和16:00相比，午夜时特异性¹²⁵I胰岛素结合显著降低。这些变化主要是由于胰岛素结合亲和力的改变，而非受体数量减少。关于血浆胰岛素水平则得到相反的结果。事实上，午夜时观察到最高的胰岛素浓度。结果表明，胰岛素受体功能的昼夜变化是对血浆胰岛素水平波动的反应。
