Poon P Y, Davis T M, Dornan T L, Turner R C
Diabetologia. 1983 Jun;24(6):433-6. doi: 10.1007/BF00257342.
The plasma activity of the lysosomal enzyme N-acetyl-beta, D-glucosaminidase (NAGase) has been shown to correlate with hyperglycaemia; their temporal relationships have been investigated. In 12 insulin-treated male diabetic patients, NAGase showed a slight diurnal variation with a nadir at 07.00 h (F = 9.54, p less than 0.001). The mean plasma glucose and NAGase fluctuated similarly (rs = 0.88, p less than 0.01) but did not correlate within individual patients. Normoglycaemia was induced in eight insulin-treated diabetic patients for 4 days but the mean NAGase did not fall significantly. Glycaemic improvement over 3 months was achieved by dietary therapy in 28 newly-presenting non-insulin-dependent diabetic patients: there were significant falls in mean fasting plasma glucose (mean +/- SD: 12.8 +/- 3.3 to 8.3 +/- 3.1 mmol/l; p less than 0.001), glycosylated haemoglobin levels (12.4 +/- 2.4 to 9.3 +/- 2.3%, p less than 0.001) and a corresponding decrease of NAGase (1.5 +/- 0.5 to 1.2 +/- 0.4 mumol 4-nitrophenyl-N-acetyl-beta-D-glucosamide released.h-1.ml-1; p less than 0.001). The change in NAGase correlated with the changes in plasma glucose and glycosylated haemoglobin levels (r = 0.61, p less than 0.025; r = 0.48, p less than 0.05, respectively). Plasma NAGase activity may be influenced by glycaemia in diabetes.
溶酶体酶N - 乙酰 - β，D - 氨基葡萄糖苷酶（NAGase）的血浆活性已被证明与高血糖相关；对它们的时间关系进行了研究。在12名接受胰岛素治疗的男性糖尿病患者中，NAGase呈现轻微的昼夜变化，在07:00时最低（F = 9.54，p < 0.001）。平均血浆葡萄糖和NAGase的波动相似（rs = 0.88，p < 0.01），但在个体患者中两者不相关。8名接受胰岛素治疗的糖尿病患者实现了4天的血糖正常，但平均NAGase并未显著下降。28名新诊断的非胰岛素依赖型糖尿病患者通过饮食疗法在3个月内实现了血糖改善：空腹血浆葡萄糖均值显著下降（均值±标准差：12.8±3.3降至8.3±3.1 mmol/L；p < 0.001），糖化血红蛋白水平下降（12.4±2.4至9.3±2.3%，p < 0.001），同时NAGase相应降低（1.5±0.5至1.2±0.4 μmol 4 - 硝基苯基 - N - 乙酰 - β - D - 氨基葡萄糖苷释放·h⁻¹·ml⁻¹；p < 0.001）。NAGase的变化与血浆葡萄糖和糖化血红蛋白水平的变化相关（r = 0.61，p < 0.025；r = 0.48，p < 0.05）。糖尿病患者的血浆NAGase活性可能受血糖影响。
