Weiss J W, Rossing T H, McFadden E R, Ingram R H
J Allergy Clin Immunol. 1983 Aug;72(2):140-4. doi: 10.1016/0091-6749(83)90521-3.
Twenty-seven subjects with asthma and normal baseline lung function were challenged with aerosols of methacholine (M) and by isocapnic hyperventilation with cold air (HV). Stimulus-effect relationships were determined for each provocational technique on separate days and were expressed as the dose required to produce a 20% fall in forced expired volume in 1 sec (FEV1) obtained by linear interpolation from log stimulus vs. response curves (PD20). Each stimulus was applied with a sufficient intensity to produce a 20% or greater fall in FEV1 in each subject. The PD20 for M correlated significantly with the PD20 for HV (p less than 0.001) when the latter was expressed in liters per minute. The correlation between cumulative M PD20 and HV PD20 expressed as a percent of maximal voluntary ventilation was significant but less strong. We conclude that the airway response to HV reflects nonspecific bronchial hyperresponsiveness and that the dose of HV is best determined as the absolute level of ventilation.
27名患有哮喘且基线肺功能正常的受试者接受了乙酰甲胆碱（M）气雾剂激发试验，并通过冷空气等容过度通气（HV）进行激发。在不同日期对每种激发技术测定刺激-效应关系，并表示为通过从对数刺激与反应曲线进行线性内插得到的使一秒用力呼气量（FEV1）下降20%所需的剂量（PD20）。每种刺激均以足够的强度施加，以使每个受试者的FEV1下降20%或更多。当以每分钟升数表示时，M的PD20与HV的PD20显著相关（p<0.001）。累积M的PD20与以最大自主通气百分比表示的HV的PD20之间的相关性显著，但强度稍弱。我们得出结论，气道对HV的反应反映了非特异性支气管高反应性，并且HV的剂量最好确定为通气的绝对水平。
