Nemazee D A, Sato V L
J Exp Med. 1983 Aug 1;158(2):529-45. doi: 10.1084/jem.158.2.529.
A/J mice were found to produce autoreactive IgM anti-IgG1 in response to secondary immunization with a number of protein antigens. No anti-IgG1 was produced after a single such immunization, indicating that antigen: IgG1 antibody complexes were responsible for inducing the autoreactive response. The size of the anti-IgG1 response was in some cases massive and of the same order of magnitude as the response to the foreign immunizing material. No significant anti-IgG2a, anti-IgG2b, or anti-IgG3 response was found in mice producing anti-IgG1. Virtually all of the anti-IgG1 material produced was of the IgM class and bound to the Fc region of autologous IgG1. A component of the anti-IgG1 was shown to be able to distinguish between the two mouse IgG1 allotypes. These results suggest that self-reactive anti-IgG is a common component of the secondary immune response of mice that may have powerful physiological and immunoregulatory effects.
研究发现，用多种蛋白质抗原对A/J小鼠进行二次免疫后，它们会产生自身反应性IgM抗IgG1。单次进行此类免疫后未产生抗IgG1，这表明抗原：IgG1抗体复合物是诱导自身反应性应答的原因。在某些情况下，抗IgG1应答的规模很大，与对外源免疫物质的应答规模相当。在产生抗IgG1的小鼠中未发现明显的抗IgG2a、抗IgG2b或抗IgG3应答。几乎所有产生的抗IgG1物质都属于IgM类，并与自体IgG1的Fc区域结合。已证明抗IgG1的一个成分能够区分两种小鼠IgG1同种异型。这些结果表明，自身反应性抗IgG是小鼠二次免疫应答的常见成分，可能具有强大的生理和免疫调节作用。
