Rachman F, Casimiri V, Psychoyos A, Bernard O
J Reprod Fertil. 1983 Sep;69(1):17-21. doi: 10.1530/jrf.0.0690017.
The distribution of IgA, IgG and IgM was studied by an immunoperoxidase technique on sections of mouse uteri at each stage of the oestrous cycle. Staining for IgG and IgA was highest at pro-oestrus, declined at oestrus and was very low during the other stages. At pro-oestrus IgG was found throughout the stroma, in the uterine lumen, and in 10% of glandular lumina; very few IgG-containing plasma cells were present. At pro-oestrus, IgA was found in the uterine lumen, and in most of the uterine glands, both in the lumen and in the epithelium; little IgA was present in the stroma. IgA-plasma cells were detected at each stage of the cycle and were particularly numerous at pro-oestrus and oestrus. These results suggest that IgA is secreted locally from plasma cells into the uterine gland through the glandular epithelium, but that IgG enters the stroma from the local capillaries. The obvious increase in IgG and IgA secretion at pro-oestrus, when plasma oestradiol levels are highest, supports the hypothesis that, during the oestrous cycle, the humoral immune response is regulated in the uterus by ovarian hormones.
采用免疫过氧化物酶技术，研究了动情周期各阶段小鼠子宫切片中IgA、IgG和IgM的分布情况。IgG和IgA染色在动情前期最高，在发情期下降，在其他阶段很低。在动情前期，IgG见于整个基质、子宫腔以及10%的腺腔；含IgG的浆细胞很少。在动情前期，IgA见于子宫腔以及多数子宫腺的腺腔和上皮；基质中IgA很少。在周期各阶段均检测到IgA浆细胞，在动情前期和发情期特别多。这些结果表明，IgA是由浆细胞通过腺上皮局部分泌到子宫腺内，但IgG是从局部毛细血管进入基质。当血浆雌二醇水平最高的动情前期，IgG和IgA分泌明显增加，这支持了如下假说：在动情周期中，子宫内的体液免疫反应受卵巢激素调节。
