Sonnex C
Department of GU Medicine, Addenbrooke's Hospital, Cambridge.
Sex Transm Infect. 1998 Feb;74(1):11-9. doi: 10.1136/sti.74.1.11.
Numerous studies have examined the influence of hormones on infectious diseases and there is now a wealth of data relating to the more specific effect of the sex hormones, oestrogen and progesterone, on urogenital infections. The interaction between these hormones and the immune system is complex and the variation of hormonal effect between species further complicates the true picture as related to humans. Although it is difficult therefore to draw general conclusions regarding predominant effects of specific hormones, there is the suggestion that oestrogen enhances the pathogenicity of many urogenital micro-organisms. Our understanding of the influential role played by sex hormones in disease pathogenesis is at an early stage and illustrates well the importance of drawing together and interpreting as a whole both epidemiological and molecular studies.
众多研究探讨了激素对传染病的影响，目前已有大量数据涉及性激素（雌激素和孕激素）对泌尿生殖系统感染的更具体作用。这些激素与免疫系统之间的相互作用很复杂，而且不同物种之间激素效应的差异使与人类相关的真实情况更加复杂。因此，尽管很难就特定激素的主要作用得出一般性结论，但有迹象表明雌激素会增强许多泌尿生殖系统微生物的致病性。我们对性激素在疾病发病机制中所起的影响作用的理解尚处于早期阶段，这很好地说明了整合并整体解读流行病学和分子研究的重要性。
